Häufigkeit und Verlauf der Hühnereiallergie bei Kleinkindern in Deutschland: die EuroPrevall-Geburtskohortenstudie [Frequency and development of hen's egg allergy in early childhood in Germany: the EuroPrevall birth cohort]
Background: The occurrence of food allergy has been increasing in the perception of both parents and paediatricians. However, true incidence and tolerance development are unclear due to a lack of good quality population- based studies. Our aim was to determine the frequency and development of hen's egg allergy during early childhood with the best diagnostic standard. Methods: For the German study center of the EuroPrevall birth cohort we included consecutively 1,570 healthy newborns from 4 Berlin university and academic teaching hospitals. Using a standardized questionnaire we interviewed the parents face-to-face at birth and after 12, 24 and 30 months by telephone. Symptomatic children were examined in the study center including double-blind placebo-controlled food challenges if food allergy was suspected. Results: 1,321 of 1,570 children (84.1%) completed the 24-months followup. In 12 children (8 boys and 4 girls) hen's egg allergy was confirmed. We estimated the 2-year hen's egg allergy incidence at 1.89% (95%-CI 1.28% - 2.69%) after correcting for eligible children whose parents refused food challenge tests. One year after the confirmed diagnosis 5 of the 12 children tolerated hen's egg, whereas 3 children were still allergic. The parents of the 4 remaining children re-jected a second challenge test. Conclusions: The incidence of confirmed hen's egg allergy during the first 2 years of life was almost 2% in Berlin children. Approximately half of these children tolerated hen's egg 1 year later. In order to again assess the allergy status of all children, follow-up examinations at school age are planned.
Eckers, N., Grabenhenrich, L., Gough, H., Reich, A., Rosenfeld, L., Niggemann, B., ... Keil, T. (2015). Häufigkeit und Verlauf der Hühnereiallergie bei Kleinkindern in Deutschland: die EuroPrevall-Geburtskohortenstudie: [Frequency and development of hen's egg allergy in early childhood in Germany: the EuroPrevall birth cohort]. Allergologie, 38(10), 507-515. https://doi.org/10.5414/alx01781