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Medicinal chemist working at a chromatograph
Services and Capabilities

Drug Discovery and Development

Collaborating with academic and commercial entities to propel drug discovery and pursue development

Our team leverages core expertise in assay development, high-throughput screening (HTS), hit-to-lead medicinal chemistry, molecular design, in vitro ADME, and in vivo pharmacokinetics (PK) to expedite the drug discovery process. We apply integrated drug development capabilities in drug metabolism and pharmacokinetics, toxicology, bioanalysis, and analytical and formulation development to support development of drug candidates from hit identification to lead optimization and proof of principle.

We conduct medicinal chemistry–driven lead optimization campaigns to convert low potency/efficacy compounds with liabilities into preclinical candidates that can enter IND-enabling studies. We also support natural products discovery and hit generation using in-house focused libraries. Our scientists also provide computational chemistry and bioinformatics support.

Relying on a half-century of experience in the discovery and development of drug candidates, we work with pharmaceutical companies and government agencies to bring new medicines to market, and to ensure the safety and efficacy of those in the marketplace.

Anchoring Research

Researchers in RTI's Technology Advancement and Commercialization laboratories use cutting edge technology to solve a wide range of challenges in the fields of human health, energy, and the environment. Our labs contain state-of-the-art equipment that facilitates our engineering innovations in carbon capture, emerging public health threats, and more.

RTI International's Laboratory Innovation

RTI’s labs house 120,000 square feet of state-of-the-art equipment and technology to drive forward our mission to improve the human condition. Our scientists are developing and testing new drug compounds and treatments for cancer, mental health conditions and substance abuse addiction. We’re tackling the world’s most critical issues including climate change and the prevalence of harmful and toxic materials in our water, air, and food.