• Journal Article

Application of countercurrent chromatography/thermospray mass spectrometry for the identification of bioactive lignans from plant natural products

Citation

Lee, Y. W., Voyksner, R., Pack, T., Cook, C., Fang, Q. C., & Ito, Y. (1990). Application of countercurrent chromatography/thermospray mass spectrometry for the identification of bioactive lignans from plant natural products. Analytical Chemistry, 62(3), 244-248.

Abstract

The versatility and resolving power of countercurrent chromatography (CCC) has been demonstrated with a newly developed analytical high-speed planet centrifuge system. Interfacing countercurrent chromatography with mass spectrometry (MS) provides a new analytical methodology that integrates the advantages of countercurrent chromatography with the low detection limit and identification capability of mass spectrometry. In this paper the capability of thermospray CCC/MS is demonstrated in identifying and validating the bioactive and structurally known lignans from a crude extract of Schisandra rubriflora Rhed et Wils, a traditional Chinese herbal medicine for treatment of hepatitis