Camptothecin analogs as potent inhibitors of topoisomerase I
Wall, M., & Wani, M. (1992). Camptothecin analogs as potent inhibitors of topoisomerase I. (U.S. Patent No. 5106742). http://patft.uspto.gov/netacgi/nph-Parser?patentnumber=5106742
Abstract
A method for synthesizing camptothecin and camptothecin analogs using a novel hydroxyl-containing tricyclic intermediate and the camptothecin analogs produced by the process. The camptothecin analogs are effective inhibitors of topoisomerase I and show anti-leukemic and anti-tumor activity.
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