Camptothecin analogs as potent inhibitors of topoisomerase I

A method for synthesizing camptothecin and camptothecin analogsusing a novel hydroxyl-containing tricyclic intermediate and thecamptothecin analogs produced by the process. The camptothecinanalogs are effective inhibitors of topoisomerase I and showanti-leukemic and anti-tumor activity.

Wall, M., & Wani, M. (1992). IPC No. U.S. Camptothecin analogs as potent inhibitors of topoisomerase I. (Patent No. 5106742).