Camptothecin analogs as potent inhibitors of topoisomerase I

Wall, M., & Wani, M. (1992). IPC No. U.S. Camptothecin analogs as potent inhibitors of topoisomerase I. (U.S. Patent No. 5106742). http://patft.uspto.gov/netacgi/nph-Parser?patentnumber=5106742

Abstract

A method for synthesizing camptothecin and camptothecin analogsusing a novel hydroxyl-containing tricyclic intermediate and thecamptothecin analogs produced by the process. The camptothecinanalogs are effective inhibitors of topoisomerase I and showanti-leukemic and anti-tumor activity.

Download/Explore

Publications Info

To contact an RTI author, request a report, or for additional information about publications by our experts, send us your request.

Recent Publications

Article

What's in a name? A data-driven method to identify optimal psychotherapy classifications to advance treatment research on co-occurring PTSD and substance use disorders
Article

Grandi Byen-supporting child growth and development through integrated, responsive parenting, nutrition and hygiene
Article

Effects of additional context information in prescription drug information sheets on comprehension and risk and efficacy perceptions
Patent

Method of making confined nanocatalysts within mesoporous materials and uses thereof