A method for synthesizing camptothecin and camptothecin analogsusing a novel hydroxyl-containing tricyclic intermediate and thecamptothecin analogs produced by the process. The camptothecinanalogs are effective inhibitors of topoisomerase I and showanti-leukemic and anti-tumor activity.
Camptothecin analogs as potent inhibitors of topoisomerase I
Wall, M., & Wani, M. (1992). IPC No. U.S. Camptothecin analogs as potent inhibitors of topoisomerase I. (U.S. Patent No. 5106742).
Abstract
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