• Patent

Camptothecin analogs as potent inhibitors of topoisomerase I

Citation

Wall, M., & Wani, M. (1992). IPC No. U.S.Camptothecin analogs as potent inhibitors of topoisomerase I (Patent No. 5106742.)

Abstract

A method for synthesizing camptothecin and camptothecin analogs using a novel hydroxyl-containing tricyclic intermediate and the camptothecin analogs produced by the process. The camptothecin analogs are effective inhibitors of topoisomerase I and show anti-leukemic and anti-tumor activity.