• Conference Proceeding

Synthesis of hemopressin by [(2+2+2+1)+2] segment condensation

Citation

Lebl, M. (Ed.). (2009). Synthesis of hemopressin by [(2+2+2+1)+2] segment condensation. In Peptides: Breaking away: The proceedings of the twenty-first American peptide symposium. June 7-12, 2009, pp. 42–43. Indiana University, Bloomington, IN: .

Abstract

Hemopressin (HP), a naturally occurring nonapeptide (Pro-Val-Asn-Phe-Lys-Phe-Leu-Ser-His-OH) derived from the alpha-chain of hemoglobin[1] has recently been identified as an endogenous selective CB1 antagonist [2]. Because of widespread interest [3] in this bioactive nonapeptide, which is reported to have been synthesized using solid phase Fmoc chemistry [1b], the National Institute on Drug Abuse (NIDA) authorized the solution phase synthesis of HP as part of its Drug Synthesis Program. The fragment condensation approach involves peptides fragments derived from synthetic intermediates that can also be used in possible structure-activity studies.