Preparation of [14C]Musk Xylol
Carbonation of the aryl lithium obtained from 5‐t‐butyl‐3‐iodotoluene with carbon‐14 labeled carbon dioxide, followed by reduction gave [ArCH3‐14C]‐5‐t‐butyl‐m‐xylene. Nitration of this material gave [ArCH3‐14C]‐5‐t‐butyl‐2,4,6‐ trinitro‐m‐xylene, known as Musk Xylol. The overall yield was 32% and the product had specific activity 19.8 mCi/mmol (66 mCi/mg) and was > 99% pure.
Lewin, A., & Ramesh, U. (1995). Preparation of [14C]Musk Xylol. Journal of Labelled Compounds and Radiopharmaceuticals, 36(6), 549-552. https://doi.org/10.1002/jlcr.2580360606