The Need for Reflective Consideration of an Integrative Understanding of Cardiovascular Consequences to PVP Formulated C60 Exposure

Timothy R. Fennell; Susan J. Sumner; Anita H. Lewin; CJ Wingard; NA Holland; Leslie C Thompson; JM Brown; Anita H. Lewin; Susan J. Sumner; Timothy R. Fennell; AK Vidanapathirana

The Need for Reflective Consideration of an Integrative Understanding of Cardiovascular Consequences to PVP Formulated C60 Exposure

Wingard, C. J., Holland, N. A., Thompson, L. C., Brown, J. M., Lewin, A., Sumner, S., Fennell, T., & Vidanapathirana, AK. (2014). The Need for Reflective Consideration of an Integrative Understanding of Cardiovascular Consequences to PVP Formulated C60 Exposure. Toxicological Sciences, 141(2), 327-328. https://doi.org/10.1093/toxsci/kfu182

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Abstract

To the Editor,
We appreciate the discussion raised in the LTE “Study examining fullerene toxicity raises questions as to the purity of the nanomaterials and erroneous experimental conclusions”. We acknowledge the potential for fullerenes and other engineered nanomaterials to have benefits, medical or otherwise. It is clear that the scientific and lay communities are excited about the possibilities that these types of materials invoke, but may need further studies if we are to understand how the body discriminates between their unique properties. We have dedicated substantial effort to studying how this fullerene, a suspension of polyvinylpyrrolidone (PVP) formulated C60 in saline, and other engineered nanomaterials may impact cardiovascular physiology...