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Hexahydroindenopyridine compounds having antispermatogenic activity

Cook, C., Jump, J., Zhang, P., Stephens, JR., Fail, P., Lee, Y., & Wani, M. (1999). Hexahydroindenopyridine compounds having antispermatogenic activity. (U.S. Patent No. 5952336). http://patft.uspto.gov/netacgi/nph-Parser?patentnumber=5952336

Abstract

Hexahydroindenopyridine compounds having the following formula and relative stereochemistry ##STR1## where R.sup.1 is C.sub.1-6 alkyl; R.sup.2 is hydrogen or C.sub.1-6 alkyl; R.sup.3 is carboxyl or a group which is metabolized to a carboxyl group under mammalian physiological conditions; R.sup.4 is halogen; mixtures of said compound and acid addition salts thereof exhibit potent antispermatogenic activity and are useful in a method of inhibiting spermatogenesis in mammals.

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