Discordance at human leukocyte antigen-DRB3 and protection from human immunodeficiency virus type 1 transmission
Host human leukocyte antigens (HLAs) integrated into the human immunodeficiency virus (HIV) type 1 envelope could theoretically determine, as in tissue transplants, whether HIV-1 is 'rejected' by exposed susceptible persons, preventing transmission. HLA discordance (mismatch) was examined among 45 heterosexual partner pairs in which at least 1 partner was HIV-1 infected and exposure or transmission between partners had occurred. Immunologic discordance at class II HLA-DRB3 (present in the HIV donor partner but absent in the recipient partner) was associated with lack of transmission of HIV-1. Eight (35%) of 23 partner pairs in which HIV-1 transmission did not occur were immunologically discordant at HLA-DRB3, compared with 0 of 11 partner pairs in which HIV-1 transmission did occur (P=.027). Further investigation of the roles of class II HLAs in HIV-1 transmission and as possible components of HIV-1 vaccines should be pursued
Hader, S. L., Hodge, T. W., Buchacz, K. A., Bray, R. A., Padian, N., Rausa, A., ... Holmberg, S. (2002). Discordance at human leukocyte antigen-DRB3 and protection from human immunodeficiency virus type 1 transmission. Journal of Infectious Diseases, 185(12), 1729-1735.