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Chemistry Services for the National Toxicology Program (NTP)

Using analytical chemistry to help screen new chemicals and contribute to toxicology science

Each year, more than 2,000 chemicals are introduced for use in commonly used items like food, personal care projects, prescription drugs, household cleaners, and lawn care products, for which approximately 80,000 chemicals are already registered for use.

All of these chemicals are evaluated by the National Toxicology Program (NTP). A unit of the Department of Health and Human Services, NTP is responsible for coordinating toxicology testing of these chemicals and providing information about potentially toxic chemicals to state and federal public health agencies.

In addition to keeping potentially dangerous chemicals out of common products, NTP also advances the science of toxicology by improving testing methods and keeping government agencies and communities up to date and well-informed.

Characterization and Dose Confirmation Help Ensure Accurate, Reliable Results of NTP Studies

Since 1984, we have provided key chemistry services in support of NTP. Our scientists perform chemical analysis in support of the NTP’s research programs, including

  • High-throughput screening
  • Analytical method development
  • Bulk chemical characterization
  • Dose formulation development and dose analysis
  • Bio sample analysis
  • Stability measurements
  • Pharmacokinetic studies.

Using reliable sources and comprehensive testing of chemicals to ensure that test substances are fully characterized and free of possible contamination, our chemists help to ensure that NTP studies generate accurate, reliable results about potential effects on public health. Our work continues under a 10-year contract awarded in 2014 to deliver test chemical characterization, dose confirmation, and internal dose determination—critical steps in NTP’s research and testing process.

Our efforts in support of NTP are an example of our ongoing commitment to research of the effects of chemical and environmental exposures on human health. Federal and local agencies rely on NTP to provide the basis for informed decisions about health safety, and NTP, in turn, relies on our analytical chemists, toxicokinetics experts, and researchers.