• Article

Synthesis of carbon-14 labeled 1-(2-hydroxyiminomethyl)-1- pyridino-3-(4-carbamoyl-1-pyridino)-2-oxapropane dichloride monohydrate ([C-14]HI-6 center dot H2O)

The synthesis of the title compound ([14C]‐2) is described. Simultaneous quaternizations of 2‐pyridine[14C]aldoxime (8) and isonicotin‐amide (10) by bis(methylsulfonoxymethyl) ether gave 1‐(2‐hydroxyimino‐[14C]methyl)‐1‐pyridino‐3‐(4‐carbamoyl‐1‐pyridino)‐2‐oxapropane dimethanesulfonate (11) which was converted to [14C]‐2 by ion‐exchange chromatography. Purification of [14C]‐2 was done by serial crystallization with isotopic dilution which gave product of 97% and 98% radiochemical and chemical purity, respectively with 3% overall radiochemical yield

Citation

Amin, M., Twine, C., & Kepler, J. (1997). Synthesis of carbon-14 labeled 1-(2-hydroxyiminomethyl)-1- pyridino-3-(4-carbamoyl-1-pyridino)-2-oxapropane dichloride monohydrate ([C-14]HI-6 center dot H2O). Journal of Labelled Compounds and Radiopharmaceuticals, 39(11), 875-884. https://doi.org/10.1002/(SICI)1099-1344(199711)39:113.0.CO;2-M