The known alkaloids nitidine chloride  and 6-oxynitidine  and a new compound 6-methoxy-5,6-dihydronitidine  have been isolated from Fagara macrophylla. Compound 3 was the major product and was shown to be an artifact. The alkaloids 1 and 3 have been interconverted by treatment of 1 under basic conditions or 3 under acidic conditions. On sublimation 1 and 3 formed 8,9-dimethoxy-2,3-methylenedioxybenzo[c]phenanthridine  which could then be converted to 5,6-dihydronitidine . The alkaloids 1 and 3 are about equipotent in P-388 mouse leukemia, giving high T/C values of 240-260% at doses of 30-50 mg/kg. The other compounds were inactive. The structural requirement for antitumor activity in the phenanthridine series is the ability to form a C-6 iminium ion
Plant antitumor agents, 27. Isolation, structure, and structure activity relationships of alkaloids from Fagara macrophylla
Wall, M., Wani, M., & Taylor, H. (1987). Plant antitumor agents, 27. Isolation, structure, and structure activity relationships of alkaloids from Fagara macrophylla. Journal of Natural Products, 50(6), 1095-1099.