• Patent

Synthesis of camptothecin and analogs thereof


Wall, M., Wani, M., Nicholas, A., & Manikumar, G. (1991). IPC No. U.S.Synthesis of camptothecin and analogs thereof (Patent No. 4981968.)


A method for synthesizing camptothecin and camptothecin analogs using a novel hydroxyl-containing tricyclic intermediate and the camptothecin analogs produced by the process. The camptothecin analogs are effective inhibitors of topoisomerase I and show anti-leukemic and anti-tumor activity.