• Article

Smoking and risk of leukemia

The relation between tobacco use and leukemia was evaluated in a population-based case-control study of 578 white men with leukemia and 820 controls conducted in Iowa and Minnesota during 1981-1984. Risks were significantly elevated for all leukemia (odds ratio (OR) = 1.4) and chronic lymphocytic leukemia (OR = 1.6) for both tobacco users and cigarette smokers. There were significantly elevated risks for cigarette smokers of longest duration for all leukemia (OR = 1.6), chronic myelogenous leukemia (OR = 3.3), and chronic lymphocytic leukemia (OR = 1.6). Thus, the findings of this study provide additional support for an association between smoking and the risk of several types of leukemia


Brown, L., Gibson, R., Blair, A., Burmeister, LF., Schuman, LM., Cantor, KP., & Fraumeni, JF. (1992). Smoking and risk of leukemia. American Journal of Epidemiology, 135(7), 763-768.