Assigning a cause to an individual event is a natural impulse. This impulse sometimes finds its way into epidemiologic research, if researchers assign a specific cause to some cases of a disease under study. In epidemiologic studies of drug effects, assigning a cause to specific cases is often used as a reason to exclude these cases from cohort or case-control studies, because the disease in these cases is thought to be the result of a 'known cause'. These exclusions are invalid. It is always valid, however, to exclude all subjects with 'known' causes from a study, cases from the numerator and the people or person-time at risk from the denominator (or from the control series in a case-control study). If the exclusions from the denominator would be negligibly small or the relative number of excluded cases with 'known' causes is small, then the exclusion of just the cases with 'known' causes will introduce little bias. Copyright (C) 2002 John Wiley Sons, Ltd
Should cases with a 'known' cause of their disease be excluded from study? (Commentary)
Rothman, K., & Ray, W. (2002). Should cases with a 'known' cause of their disease be excluded from study? (Commentary). Pharmacoepidemiology and Drug Safety, 11(1), 11-14.
Abstract
Publications Info
To contact an RTI author, request a report, or for additional information about publications by our experts, send us your request.
Meet the Experts
View All ExpertsRecent Publications
Article
Use of a web-based portal to return normal individual research results in Early Check
Article
Personal exposure to PM2.5 in different microenvironments and activities for retired adults in two megacities, China
Article
Estimating global artisanal fishing fleet responses in an era of rapid climate and economic change
Article