Novel bioactive phenanthrene derivatives from Domohinea perrieri
Long, L., Lee, S. K., Chai, H. B., Rasoanaivo, P., Gao, Q., Navarro, H., ... Kinghorn, A. D. (1997). Novel bioactive phenanthrene derivatives from Domohinea perrieri. Tetrahedron, 53(46), 15663-15670.
Four novel phenanthrene derivatives were isolated from
Domohinea perrieri Leandri (Euphorbiaceae) collected in Madagascar, and
have been structurally assigned as
3,6-dihydroxy-7-hydroxymethyl-9-methoxy-1-methylphenanthrene (3), and
respectively. A further constituent was the navel hexahydrophenanthrene
derivative, domohinone (5), whose structure was confirmed by
single-crystal X-ray crystallography. Compounds 1-5 were evaluated for
cytotoxic and bleomycin-mediated DNA strand-scission activities.