• Article

Novel bioactive phenanthrene derivatives from Domohinea perrieri


Long, L., Lee, S. K., Chai, H. B., Rasoanaivo, P., Gao, Q., Navarro, H., ... Kinghorn, A. D. (1997). Novel bioactive phenanthrene derivatives from Domohinea perrieri. Tetrahedron, 53(46), 15663-15670.


Four novel phenanthrene derivatives were isolated from

Domohinea perrieri Leandri (Euphorbiaceae) collected in Madagascar, and

have been structurally assigned as

3,6-dihydroxy-1,7-dimethyl-9-methoxyphenanthrene (1),

3,6-dihydroxy-1-hydroxymethyl-9-methoxy-7-methylphenanthrene (2),

3,6-dihydroxy-7-hydroxymethyl-9-methoxy-1-methylphenanthrene (3), and

3,6-dihydroxy-1,7-dihydroxymethyl-9-methoxyphenanthrene (4),

respectively. A further constituent was the navel hexahydrophenanthrene

derivative, domohinone (5), whose structure was confirmed by

single-crystal X-ray crystallography. Compounds 1-5 were evaluated for

cytotoxic and bleomycin-mediated DNA strand-scission activities.