• Journal Article

Novel bioactive phenanthrene derivatives from Domohinea perrieri


Long, L., Lee, S. K., Chai, H. B., Rasoanaivo, P., Gao, Q., Navarro, H., ... Kinghorn, A. D. (1997). Novel bioactive phenanthrene derivatives from Domohinea perrieri. Tetrahedron, 53(46), 15663-15670.


Four novel phenanthrene derivatives were isolated from Domohinea perrieri Leandri (Euphorbiaceae) collected in Madagascar, and have been structurally assigned as 3,6-dihydroxy-1,7-dimethyl-9-methoxyphenanthrene (1), 3,6-dihydroxy-1-hydroxymethyl-9-methoxy-7-methylphenanthrene (2), 3,6-dihydroxy-7-hydroxymethyl-9-methoxy-1-methylphenanthrene (3), and 3,6-dihydroxy-1,7-dihydroxymethyl-9-methoxyphenanthrene (4), respectively. A further constituent was the navel hexahydrophenanthrene derivative, domohinone (5), whose structure was confirmed by single-crystal X-ray crystallography. Compounds 1-5 were evaluated for cytotoxic and bleomycin-mediated DNA strand-scission activities.