Novel bioactive phenanthrene derivatives from Domohinea perrieri
Four novel phenanthrene derivatives were isolated from
Domohinea perrieri Leandri (Euphorbiaceae) collected in Madagascar, and
have been structurally assigned as
3,6-dihydroxy-7-hydroxymethyl-9-methoxy-1-methylphenanthrene (3), and
respectively. A further constituent was the navel hexahydrophenanthrene
derivative, domohinone (5), whose structure was confirmed by
single-crystal X-ray crystallography. Compounds 1-5 were evaluated for
cytotoxic and bleomycin-mediated DNA strand-scission activities.
Long, L., Lee, SK., Chai, HB., Rasoanaivo, P., Gao, Q., Navarro, H., ... Kinghorn, AD. (1997). Novel bioactive phenanthrene derivatives from Domohinea perrieri. Tetrahedron, 53(46), 15663-15670.