Metabolomics applied to the pancreatic islet
Gooding, J. R., Jensen, M. V., & Newgard, C. B. (2016). Metabolomics applied to the pancreatic islet. Archives of Biochemistry and Biophysics, 589, 120-130. DOI: 10.1016/j.abb.2015.06.013
Metabolomics, the characterization of the set of small molecules in a biological system, is advancing research in multiple areas of islet biology. Measuring a breadth of metabolites simultaneously provides a broad perspective on metabolic changes as the islets respond dynamically to metabolic fuels, hormones, or environmental stressors. As a result, metabolomics has the potential to provide new mechanistic insights into islet physiology and pathophysiology. Here we summarize advances in our understanding of islet physiology and the etiologies of type-1 and type-2 diabetes gained from metabolomics studies. (C) 2015 Elsevier Inc. All rights reserved.