• Article

Limitations on the Uses of Multimedia Exposure Measurements for Multipathway Assessment-PartI: Handling Observations Below Detection Limits

Multimedia data from two probability-based exposure studies were investigated in terms of how censoring of nondetects affected estimation of population parameters and associations. Appropriate methods for handling censored below-detection-limit(BDL)values in this context were unclear since sampling weights were involved and since bivariate associations/measures were of interest. Both simple substitution(e.g., using 1/2 or 2/3 of the detection limit(DL)for BDL values)and truncation-based strategies were investigated by creating some artificial DLs and comparing resultant estimates with the original studies'uncensored results. The substitution methods generally outperformed the truncation methods, with the(2/3)DL substitution generally performing best.

Citation

Clayton, C., Mosquin, P., Pellizzari, E., & Quackenboss, J. (2003). Limitations on the Uses of Multimedia Exposure Measurements for Multipathway Assessment-PartI: Handling Observations Below Detection Limits. Quality assurance (San Diego, Calif.), Vol. 10(3-4), 123 - 159.