Interest in “drugging” has increased, with much focus on drugging victimization within the context of sexual assault and particularly among college students. This study uses data from the Campus Sexual Assault (CSA) Study and the Historically Black College and University Campus Sexual Assault (HBCU-CSA) Study to explore college women’s drugging victimization experiences beyond those limited to drug-facilitated sexual assault. We draw on a lifestyle-exposure/routine activity theory approach to personal victimization integrated with scholarship on gendered opportunities and the campus party culture to examine the individual, behavioral, and situational characteristics embedded in the campus environment that place college women at increased risks of being drugged. We pay particular attention to cultural and institutional differences shaping experiences and risks at predominantly White institutions (PWIs) and Historically Black Colleges and Universities (HBCUs). Findings show that 5% and 4% of women at PWIs and HBCUs, respectively, report drugging victimization and that exposure to risky situations (e.g., fraternity party attendance) is a risk factor primarily for women at PWIs.