Inhaled therapies offer a unique approach to the treatment of tuberculosis (TB) using a relevant target organ system as a route of administration. The number of research reports on this topic has been increasing exponentially in the last decade but studies of clinical efficacy have been rare in recent times. The challenge is to take many research findings and translate them into a strategy for product development. Dry powder inhalers are the dominant drug product under consideration by those interested in the inhaled therapy for TB. A range of factors including candidate drug, formulation, device selection, drug product testing for proof of concept, and preclinical and clinical purposes all demand different considerations. The following review is intended to raise awareness of a growing body of evidence, suggesting that inhaled therapy for TB is possible and desirable. In addition, it is intended to outline key elements of the product-development activity for this particular application that has not been discussed elsewhere in the literature. Hopefully, this will encourage those with development expertise to seriously contemplate the steps required to bring such products forward. (c) 2013 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci
Dry Powder Antibiotic Aerosol Product Development: Inhaled Therapy for Tuberculosis
Hickey, A., Misra, A., & Fourie, PB. (2013). Dry Powder Antibiotic Aerosol Product Development: Inhaled Therapy for Tuberculosis. Journal of Pharmaceutical Sciences, 102(11), 3900-3907. https://doi.org/10.1002/jps.23705
Abstract
Publications Info
To contact an RTI author, request a report, or for additional information about publications by our experts, send us your request.
Meet the Experts
View All ExpertsRecent Publications
Article
Treatment preferences among patients with mild-to-moderate atopic dermatitis
Article
Multifaceted risk for non-suicidal self-injury only versus suicide attempt in a population-based cohort of adults
Article
Spatiotemporal analysis exploring the effect of law enforcement drug market disruptions on overdose, Indianapolis, Indiana, 2020-2021
Article