• Patent

Configurationally locked retinoids

A group of retinoids having "vitamin A type" activity which havethe structure ##STR1## wherein R3 is atrimethylcyclohexenylethylene, tetramethyltetrahydronaphthalene ormethoxytrimethylphenylethylene group; R1 and R2 which are differentare selected from --OH, --OR4 and --NHR, provided one of R1 and R2is OH; R4 is alkyl of 1 to 20 carbons; and R is selected from thegroup consisting of hydrogen, alkyl of 1 to 4 carbons, hydroxyalkylof 1 to 4 carbons, alkylhydroxyalkyl of 1 to 4 carbons, phenyl,hydroxyphenyl and carboxyphenyl, and R5 is a lactone or lactam ofthe structure ##STR2## and X is oxygen or NR where R is as above,and the pharmaceutically acceptable salts thereof.


Carroll, F., & Lewin, A. (1986). IPC No. U.S. Configurationally locked retinoids. (Patent No. 4568757).