• Article

Enantioselective synthesis and pharmacology of 11-hydroxy-(1 ' S,2 ' R)-dimethylheptyl-Delta(8)-THC

An enantioselective synthesis of the (1'S,2'R)-dimethylheptyl cannabinoid side chain has been developed and employed in the synthesis of 11-hydroxy-(1'S,2'R)-dimethylheptyl-Delta(8)-THC (3). Pharmacology, in vivo and in vitro, indicate (3) to be one of the most potent traditional cannabinoids known. (C) 1998 Elsevier Science Ltd. All rights reserved

Citation

Liddle, J., Huffman, J. W., Wiley, J., & Martin, B. R. (1998). Enantioselective synthesis and pharmacology of 11-hydroxy-(1 ' S,2 ' R)-dimethylheptyl-Delta(8)-THC. Bioorganic and Medicinal Chemistry Letters, 8(16), 2223-2226.