Tetrabenazine (1) was reduced with NaBH4 to ?-dihydrotetrabenazine (2) and then resolved with di-p-toluoyl-L-tartrate and di-p-toluoyl-D-tartrate to subsequently give (+)- and (?)-?-dihydrotetrabenazine. The enantiomers were oxidized under Swern conditions to prepare samples of (+)-tetrabenazine and (?)-tetrabenazine. The samples were optically pure by chiral HPLC analysis.
Synthesis of (+)- and (-)-tetrabenazine from the resolution of -dihydrotetrabenazine
Boldt, K., Biggers, MS., Phifer, S., Brine, G., & Rehder, K. (2009). Synthesis of (+)- and (-)-tetrabenazine from the resolution of -dihydrotetrabenazine. Synthetic Communications, 39(20), 3574-3585. https://doi.org/10.1080/00397910902788125
Abstract
Publications Info
To contact an RTI author, request a report, or for additional information about publications by our experts, send us your request.