Cocaine receptor binding ligands
Kuhar, M. J., Carroll, F., Boja, J. W., Lewin, A., & Abraham, P. (2007). IPC No. U.S.Cocaine receptor binding ligands (Patent No. 7291737.)
A class of binding ligands for cocaine receptors and otherreceptors in the brain. Specifically, a novel family of compoundsshows high binding specificity and activity, and, in a radiolabeledform, can be used to bind to these receptors, for biochemicalassays and imaging techniques. Such imaging is useful fordetermining effective doses of new drug candidates in humanpopulations. In addition, the high specificity, slow onset and longduration of the action of these compounds at the receptors makesthem particularly well suited for therapeutic uses, for example assubstitute medication for psychostimulant abuse. Some of thesecompounds may be useful in treating Parkinson's Disease ordepression, by virtue of their inhibitory properties at monoaminetransporters.