• Patent

10,11-methylenedioxy-20(RS)-camptothecin analogs

A camptothecin analog having the structure shown below: ##STR1##wherein R is NO.sub.2, NH.sub.2, NHCOCHR.sup.1 NR.sup.2 R.sup.3,where R.sup.1 is the side-chain of an .alpha.-amino acid andR.sup.2 and R.sup.3, independently are hydrogen or a lower alkylgroup or R.sup.3 is a peptide unit containing 1-3 amino acid unitsbonded to the nitrogen through a peptide bond, NHCO--C.sub.2-8-alkylene-X or NHCO--C.sub.2-8 -alkenylene-X, where X is COOH orCONR.sup.2 --(CH.sub.2).sub.n --NR.sup.2 R.sup.3, n=1-10 andR.sup.2 and R.sup.3 are as defined above, NHCO--Z--(CH.sub.2).sub.n--NR.sup.2 R.sup.3, where z=oxygen or NH, or ##STR2## where m+y=3-6and salts thereof.


Wall, M., Wani, M., Nicholas, A., & Manikumar, G. (1991). IPC No. U.S. 10,11-methylenedioxy-20(RS)-camptothecin analogs. (Patent No. 5049668).