RTI uses cookies to offer you the best experience online. By clicking “accept” on this website, you opt in and you agree to the use of cookies. If you would like to know more about how RTI uses cookies and how to manage them please view our Privacy Policy here. You can “opt out” or change your mind by visiting: http://optout.aboutads.info/. Click “accept” to agree.
A camptothecin analog having the structure shown below: ##STR1##
wherein R is NO.sub.2, NH.sub.2, NHCOCHR.sup.1 NR.sup.2 R.sup.3,
where R.sup.1 is the side-chain of an .alpha.-amino acid and
R.sup.2 and R.sup.3, independently are hydrogen or a lower alkyl
group or R.sup.3 is a peptide unit containing 1-3 amino acid units
bonded to the nitrogen through a peptide bond, NHCO--C.sub.2-8
-alkylene-X or NHCO--C.sub.2-8 -alkenylene-X, where X is COOH or
CONR.sup.2 --(CH.sub.2).sub.n --NR.sup.2 R.sup.3, n=1-10 and
R.sup.2 and R.sup.3 are as defined above, NHCO--Z--(CH.sub.2).sub.n
--NR.sup.2 R.sup.3, where z=oxygen or NH, or ##STR2## where m+y=3-6
and salts thereof.
RTI shares its evidence-based research - through peer-reviewed publications and media - to ensure that it is accessible for others to build on, in line with our mission and scientific standards.