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Search Results

Showing results 1 to 20 of 74.


Functionalized 6-(piperidin-1-yl)-8,9-diphenyl purines as inverse agonists of the CB1 receptor - SAR efforts towards selectivity and peripheralization

August 15, 2019

The monoacylglycerol lipase inhibitor ABX-1431 does not improve alcoholic liver disease

May 29, 2023

Apelin receptor (APJ) agonists and uses thereof

August 02, 2022

Dual-acting cholinesterase-human cannabinoid receptor 2 ligands show pronounced neuroprotection in vitro and overadditive and disease-modifying neuroprotective effects in vivo

October 24, 2019

Pyrazole agonist of the apelin receptor improves symptoms of metabolic syndrome in mice

March 25, 2021

A disease-relevant high-content screening assay to identify anti-inflammatory compounds for use in cystic fibrosis

December 01, 2010

READDI Forethought uses the power of collaboration to accelerate scientific discovery

October 11, 2022

Peripherally selective CB1 receptor antagonist improves symptoms of metabolic syndrome in mice

April 09, 2021

Metabolic profiling of CB1 neutral antagonists: (Chapter 9)

July 01, 2017

Peripherally Selective Diphenyl Purine Antagonist of the CB1 Receptor

September 27, 2013

Development of a peripherally restricted cb1 receptor antagonist for alcoholic steatosis

October 01, 2017
RTI In The Media

Modifying an obesity drug could reduce side effects like anxiety and depression

April 29, 2016 - Medical News Today

Discovery of a potent, selective, and brain-penetrant small molecule that activates the orphan receptor GPR88 and reduces alcohol intake

August 09, 2018

Design, Synthesis, and Biological Evaluation of (3R)-1,2,3,4-Tetrahydro-7-hydroxy-N-[(1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dim ethyl-1-piperidinyl]methyl]-2-methylpropyl]-3-isoquinolinecarboxamide (JDTic) Analogues: In Vitro Pharmacology and ADME Profi

September 11, 2014

Discovery of a novel small molecule agonist scaffold for the APJ receptor

August 15, 2016
News Release

Modifying an obesity drug could reduce side effects like anxiety and depression

March 23, 2016

Evaluation of amide bioisosteres leading to 1,2,3-triazole containing compounds as GPR88 agonists: Design, synthesis, and structure-activity relationship studies

August 26, 2021

Design, synthesis, and pharmacological evaluation of JDTic analogs to examine the significance of the 3-and 4-methyl substituents

October 01, 2015

"Photo-Rimonabant": Synthesis and biological evaluation of novel photoswitchable molecules derived from Rimonabant lead to a highly selective and nanomolar "Cis-On" CB1R antagonist

May 05, 2021

Structural analogs of pyrazole and sulfonamide cannabinoids: Effects on acute food intake in mice

November 01, 2012