Synthesis of triple (13C2, 15N), single (14C), and double (14C2) labeled trimetrexate
A method was developed for the synthesis of triple (13C2, 14N) labeled trimetrexate. A method for single carbon‐14 labeled synthesis is also described. Modifications of the triple labeled synthesis with carbon‐14 produced a doubled carbon‐14 labeled trimetrexate.
Hicks, J. L., Hartman, J. D., Skeean, R. W., Huang, C. C., Kepler, J., & Liang, C-H. (1991). Synthesis of triple (13C2, 15N), single (14C), and double (14C2) labeled trimetrexate. Journal of Labelled Compounds and Radiopharmaceuticals, 29(4), 415-429. https://doi.org/10.1002/jlcr.2580290407