Synthesis of camptothecin and analogs thereof

A method for synthesizing camptothecin and camptothecin analogsusing a novel hydroxyl-containing tricyclic intermediate and thecamptothecin analogs produced by the process. The camptothecinanalogs are effective inhibitors of topoisomerase I and showanti-leukemic and anti-tumor activity.

Wall, M., Wani, M., Nicholas, A., & Manikumar, G. (1990). IPC No. U.S.Synthesis of camptothecin and analogs thereof (Patent No. 4894456.)