A method for synthesizing camptothecin and camptothecin analogsusing a novel hydroxyl-containing tricyclic intermediate and thecamptothecin analogs produced by the process. The camptothecinanalogs are effective inhibitors of topoisomerase I and showanti-leukemic and anti-tumor activity.
Synthesis of camptothecin and analogs thereof
Wall, M., Wani, M., Nicholas, A., & Manikumar, G. (1990). IPC No. U.S. Synthesis of camptothecin and analogs thereof. (U.S. Patent No. 4894456). http://patft.uspto.gov/netacgi/nph-Parser?patentnumber=4894456