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Total synthesis of 20(S) and 20(R)-camptothecin and compthothecin derivatives

Wani, M., Nicholas, A., & Wall, M. (1991). Total synthesis of 20(S) and 20(R)-camptothecin and compthothecin derivatives. (U.S. Patent No. 5053512). http://patft.uspto.gov/netacgi/nph-Parser?patentnumber=5053512

Abstract

The invention relates to a method of producing 20(S)-comptothecin, 20(R)-camptothecin and analogs thereof. The method involves the resolution of an mixture of enantiomers of an intermediate lactone.

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