The invention relates to a method of producing20(S)-comptothecin, 20(R)-camptothecin and analogs thereof. Themethod involves the resolution of an mixture of enantiomers of anintermediate lactone.
Total synthesis of 20(S) and 20(R)-camptothecin and compthothecin derivatives
Wani, M., Nicholas, A., & Wall, M. (1991). IPC No. U.S. Total synthesis of 20(S) and 20(R)-camptothecin and compthothecin derivatives. (U.S. Patent No. 5053512). http://patft.uspto.gov/netacgi/nph-Parser?patentnumber=5053512
Abstract
Abstract
Publications Info
To contact an RTI author, request a report, or for additional information about publications by our experts, send us your request.