The invention relates to a method of producing20(S)-comptothecin, 20(R)-camptothecin and analogs thereof. Themethod involves the resolution of an mixture of enantiomers of anintermediate lactone.
Total synthesis of 20(S) and 20(R)-camptothecin and compthothecin derivatives
Wani, M., Nicholas, A., & Wall, M. (1991). IPC No. U.S. Total synthesis of 20(S) and 20(R)-camptothecin and compthothecin derivatives. (U.S. Patent No. 5053512).
Abstract
Abstract
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