• Patent

Total synthesis of 20(S) and 20(R)-camptothecin and compthothecin derivatives

Citation

Wani, M., Nicholas, A., & Wall, M. (1991). IPC No. U.S.Total synthesis of 20(S) and 20(R)-camptothecin and compthothecin derivatives (Patent No. 5053512.)

Abstract

The invention relates to a method of producing 20(S)-comptothecin, 20(R)-camptothecin and analogs thereof. The method involves the resolution of an mixture of enantiomers of an intermediate lactone.