• Journal Article

Stereospecific synthesis of amphetamines

Citation

Wagner, J., McElhinny, C., Lewin, A., & Carroll, F. (2003). Stereospecific synthesis of amphetamines. Tetrahedron: Asymmetry, 14(15), 2119-2125. DOI: 10.1016/S0957-4166(03)00438-5

Abstract

Regioselective addition of aryl lithium to commercially available (S)-(+)-propylene oxide provides the corresponding (S)-aryl-2-propanol. The (R)-amphetamine is obtained by conversion of the alcohol to the tosylate followed by azide displacement and hydrogenation. Mitsunobu conversion of the alcohol to the (R)-bromide followed by azide displacement and hydrogenation affords the (S)-amphetamine. (C) 2003 Elsevier Ltd. All rights reserved