A selective delta opioid receptor antagonist based on a stilbene core
Hartung, A. M., Navarro, H., Wiemer, D. F., & Neighbors, J. D. (2015). A selective delta opioid receptor antagonist based on a stilbene core. Bioorganic and Medicinal Chemistry Letters, 25(23), 5532-5535. DOI: 10.1016/j.bmcl.2015.10.059
Studies of directed ortho metalation reactions on an aromatic substrate with multiple potential directing groups have identified conditions that favor either of two regioisomers. One of these regioisomers has been converted to an analogue of the stilbene pawhuskin A, and been shown to have high selectivity as an antagonist of the delta opioid receptor. Docking studies have suggested that this compound can adopt a conformation similar to naltrindole, a known delta antagonist. (C) 2015 Elsevier Ltd. All rights reserved.