Metal-catalysed exchange with tritiated water and tritium gas has been extensively used to prepare a wide range of tritium-labelled compounds in support of pharmaceutical research. Examples of the utility of both heterogeneous and homogeneous metal catalysts to label a very broad range of structures will be discussed in this review.
Tritium labelling of pharmaceuticals by metal-catalysed exchange methods
Hesk, D., Lavey, C. F., & McNamara, P. (2010). Tritium labelling of pharmaceuticals by metal-catalysed exchange methods. Journal of Labelled Compounds and Radiopharmaceuticals, 53(11-12), 722-730. https://doi.org/10.1002/jlcr.1800
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