• Journal Article

Synthesis of hemopressin peptides by classical solution phase fragment condensation

Citation

Reddy, P., Jones, S., Lewin, A., & Carroll, F. (2012). Synthesis of hemopressin peptides by classical solution phase fragment condensation. International Journal of Peptides, 2012, Article ID 186034. DOI: 10.1155/2012/186034

Abstract

A fragment condensation solution phase assembly of the naturally occurring CB1 inverse agonist nonapeptides, Pro-Val-Asn-Phe-Lys-Phe/Leu-Leu-Ser-His-OH (hemopressins), and two other homologues: N-terminal 2-amino acid (dipeptide) extended undecapeptide, Val-Asp-Pro-Val-Asn-Phe-Lys-Leu-Leu-Ser-His-OH, and three-amino acid (tripeptide) extended dodecapeptide, Arg-Val-Asp-Pro-Val-Asn-Phe-Lys-Leu-Leu-Ser-His-OH, both CB1 agonists, is reported.