Synthesis of a bistetrahydrofuran C17-C32 fragment of the polyether antibiotic ionomycin

A Zn-initiated triepoxide cascade cyclization reaction was employed for the synthesis of the bistetrahydrofuran core segment of the polyether ionophore antibiotic ionomycin.

Marshall, JA., & Mikowski, AM. (2006). Synthesis of a bistetrahydrofuran C17-C32 fragment of the polyether antibiotic ionomycin. Organic Letters, 8(19), 4375-4378. https://doi.org/10.1021/ol061826u