• Journal Article

A stereoselective synthetic approach to N-alkyl-4 beta-methyl- 5-phenylmorphans

Citation

Thomas, J., Gigstad, K., Fix, S., Burgess, J., Cooper, J., Mascarella, S., ... Carroll, F. (1999). A stereoselective synthetic approach to N-alkyl-4 beta-methyl- 5-phenylmorphans. Tetrahedron Letters, 40(3), 403-406. DOI: 10.1016/S0040-4039(98)02402-2

Abstract

A convergent, highly stereoselective synthetic approach to N-alkyl-4?-methyl-5-phenylmorphans has been developed utilizing alkylation of the metalloenamine of N-alkyl-1,2,3,6-tetrahydro-4-phenylpyridines with 2-(chloromethyl)-3,5-dioxahex-1-ene (Okahara's reagent) followed by Clemmensen reduction.