• Patent

Ligands for .alpha.-7 nicotinic acetylcholine receptors based on methyllcaconitine

Citation

Carroll, F., Navarro, H., Abraham, P., & Zhong, D. (2002). IPC No. U.S.Ligands for .alpha.-7 nicotinic acetylcholine receptors based on methyllcaconitine (Patent No. 6416735.)

Abstract

Ligands for nAChRs are provided based on various derivatives of methyllycaconitine (MLA) such as radiolabeled MLA, and MLA containing a fluorimetric marker group and their use in imaging for detection of Alzheimer's and other CNS diseases, and combinatorial assays for detection of compounds having affinity for nAChRs, as well as injectable compositions containing the same and kits for performing the imaging studies.