Ligands for .alpha.-7 nicotinic acetylcholine receptors based on methyllcaconitine
Ligands for nAChRs are provided based on various derivatives ofmethyllycaconitine (MLA) such as radiolabeled MLA, and MLAcontaining a fluorimetric marker group and their use in imaging fordetection of Alzheimer's and other CNS diseases, and combinatorialassays for detection of compounds having affinity for nAChRs, aswell as injectable compositions containing the same and kits forperforming the imaging studies.
Carroll, F., Navarro, H., Abraham, P., & Zhong, D. (2002). IPC No. U.S.Ligands for .alpha.-7 nicotinic acetylcholine receptors based on methyllcaconitine (Patent No. 6416735.)