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Integrated framework for assessing multi-level determinants of HIV acquisition affecting adolescent girls and young women in sub-Saharan Africa
Assessing risk and protective factors (INFORM-HERS)
Al-Mujtaba, M., Relf, M. V., Nyblade, L. C., & Mulawa, M. I. (2026). Integrated framework for assessing multi-level determinants of HIV acquisition affecting adolescent girls and young women in sub-Saharan Africa: Assessing risk and protective factors (INFORM-HERS). Advances in Nursing Science. Advance online publication. https://doi.org/10.1097/ANS.0000000000000646
Adolescent girls and young women (AGYW) aged 15 to 24 face disproportionate human immunodeficiency virus acquisition risk in sub-Saharan Africa, yet existing frameworks inadequately address their multilevel, gender-specific determinants. We developed INFORM-HERS (INtegrated Framework fOR assessing Multilevel determinants of human immunodeficiency virus acquisition among AGYW) using "Up and Down" theory integration of 3 established frameworks: Theory of Gender and Power, Modified Social Ecological Model, and Center for Latino Adolescent and Family Health Framework of Social Determinants of Health Mechanisms. INFORM-HERS incorporates gender inequality risk factors, social protective factors, and AGYW-specific developmental transitions, providing a theoretical foundation for multilevel interventions in sub-Saharan Africa.
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