Enzymatic approach toward the synthesis of isotopically labeled (R)-9-(2-hydroxypropyl)adenine

Rivera, N. R., Moore, J., Schenk, D. J., Wang, H., Hesk, D., & Mergelsberg, I. (2016). Enzymatic approach toward the synthesis of isotopically labeled (R)-9-(2-hydroxypropyl)adenine. Tetrahedron Letters, 57(10), 1090-1092. https://doi.org/10.1016/j.tetlet.2016.01.087

Abstract

Isotopically labeled compounds have numerous applications in drug discovery and development. (R)-9-(2-Hydroxypropyl)adenine 1 is an important intermediate in the synthesis of various acyclic nucleoside phosphonates including tenofovir. We have developed a short synthetic method to prepare deuterium and tritium labeled 1 using a ketoreductase enzyme catalyzed reduction as the key step to introduce the label in a highly efficient and enantioselective way. (C) 2016 Elsevier Ltd. All rights reserved.

Publications Info

To contact an RTI author, request a report, or for additional information about publications by our experts, send us your request.

Recent Publications

Article

The daily association between affect and alcohol use: A meta-analysis of individual participant data
Article

Protection of forest ecosystems in the eastern United States from elevated atmospheric deposition of sulfur and nitrogen
Article

The use of patient experience feedback in rehabilitation quality improvement and codesign activities
Article

SPTSSA variants alter sphingolipid synthesis and cause a complex hereditary spastic paraplegia