Camptothecin and analogs thereof and pharmaceutical compositions and method using them

A method for synthesizing camptothecin and camptothecin analogsusing a novel hydroxyl-containing tricyclic intermediate and thecamptothecin analogs produced by the process. The camptothecinanalogs are effective inhibitors of topoisomerase I and showanti-leukemic and anit-tumor activity.

Wall, M., Wani, M., Nicholas, A., & Manikumar, G. (1992). IPC No. U.S.Camptothecin and analogs thereof and pharmaceutical compositions and method using them (Patent No. 5122526.)