Camptothecin and analogs thereof and pharmaceutical compositions and method using them

Wall, M., Wani, M., Nicholas, A., & Manikumar, G. (1992). Camptothecin and analogs thereof and pharmaceutical compositions and method using them. (U.S. Patent No. 5122526). http://patft.uspto.gov/netacgi/nph-Parser?patentnumber=5122526

Abstract

A method for synthesizing camptothecin and camptothecin analogsusing a novel hydroxyl-containing tricyclic intermediate and thecamptothecin analogs produced by the process. The camptothecinanalogs are effective inhibitors of topoisomerase I and showanti-leukemic and anit-tumor activity.

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