• Patent

Camptothecin and analogs thereof and pharmaceutical compositions and method using them

Citation

Wall, M., Wani, M., Nicholas, A., & Manikumar, G. (1992). IPC No. U.S.Camptothecin and analogs thereof and pharmaceutical compositions and method using them (Patent No. 5122526.)

Abstract

A method for synthesizing camptothecin and camptothecin analogs using a novel hydroxyl-containing tricyclic intermediate and the camptothecin analogs produced by the process. The camptothecin analogs are effective inhibitors of topoisomerase I and show anti-leukemic and anit-tumor activity.