David Hesk

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Palladium mediated C-H tritiation

Electrochemical bromination of late stage intermediates and drug molecules

Synthesis of H-3, H-2(4), and C-14-MK 3814 (preladenant)

Synthesis of 3H, 2H4, and 14C‐MK 3814 (preladenant)

Quantitation of wall teichoic acid in Staphylococcus aureus by direct measurement of monomeric units using LC-MS/MS

Twelfth International Isotope Symposium on the Synthesis and Applications of Isotopes and Isotopically Labelled Compounds (IIS2015)

Preclinical Characterization of 18F-MK-6240, a Promising PET Tracer for In Vivo Quantification of Human Neurofibrillary Tangles

Electrochemical halogenation: A new method to synthesize intermediates for tritium labeling

Synthesis and preliminary PET imaging studies of [18F]MK-6240: A radiotracer for imaging neurofibrillary tangles (NFTs) in Alzheimer's disease

Synthesis of [(14) C]omarigliptin

Discovery of 6-(Fluoro-(18)F)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine ([(18)F]-MK-6240): A positron emission tomography (PET) imaging agent for quantification of neurofibrillary tangles (NFTs)

Synthesis of (3) H, (2) H4 and (14) C-SCH 417690 (Vicriviroc)

Discovery of novel chiral 3o-SMe pyrrolidine as extracellular regulated kinase (ERK) inhibitors

Enzymatic approach toward the synthesis of isotopically labeled (R)-9-(2-hydroxypropyl)adenine

Iron-catalysed tritiation of pharmaceuticals

In vitro pharmacological characterization of vorapaxar, a novel platelet thrombin receptor antagonist

NMR-based approach to the analysis of radiopharmaceuticals: Radiochemical purity, specific activity, and radioactive concentration values by proton and tritium NMR spectroscopy

Synthesis of H-3, C-13, H-2(3),N-15 and C-14-labelled SCH 466036, a histamine 3 receptor antagonist

Synthesis of a [C-14]-steroid intermediate: An application of a nonstabilized Horner-Wadsworth-Emmons olefination approach

Synthesis of [H-3], [C-13(3), N-15], and [C-14]SCH 900567: An inhibitor of TNF-alpha (tumor necrosis factor alpha) converting enzyme (TACE)