Vicriviroc or SCH 417690 is a potent and selective antagonist of the CCR5 receptor. CCR5 receptor antagonists have the potential for the treatment of HIV infections. Four distinct isotopically labelled forms of SCH 417690 were synthesized. Low specific activity [H-3]SCH 417690 was prepared for a preliminary absorption, distribution, metabolism and excretion evaluation of the compound and [C-14]SCH 417690 for more definitive absorption, distribution, metabolism and excretion work, including an absorption, metabolism and excretion study in man. In addition, high specific activity [H-3]SCH 417690 was prepared for CCR5 receptor binding work and [H-2(4)]SCH 417690 was prepared as an internal standard for a liquid chromatography-mass spectrometry bioanalytical method. The paper discusses the synthesis of four isotopically labelled forms of SCH 417690.
Synthesis of H-3, H-2(4) and C-14-SCH 417690 (Vicriviroc)
Hesk, D., Borges, S., Hendershot, S., Koharski, D., McNamara, P., Ren, S., Saluja, S., Truong, V., & Voronin, K. (2016). Synthesis of H-3, H-2(4) and C-14-SCH 417690 (Vicriviroc). Journal of Labelled Compounds and Radiopharmaceuticals, 59(5), 190-196. https://doi.org/10.1002/jlcr.3387
Abstract
Publications Info
To contact an RTI author, request a report, or for additional information about publications by our experts, send us your request.
Meet the Experts
View All ExpertsRecent Publications
OCCASIONAL PAPER
Bringing an equity-centered framework to research
OCCASIONAL PAPER
The Preschool Entitlement
OCCASIONAL PAPER
Culturally informed community engagement
Article