Synthesis of a [C-14]-steroid intermediate

An application of a nonstabilized Horner-Wadsworth-Emmons olefination approach

Rivera, N. R., Ren, S., & Hesk, D. (2015). Synthesis of a [C-14]-steroid intermediate: An application of a nonstabilized Horner-Wadsworth-Emmons olefination approach. Journal of Labelled Compounds and Radiopharmaceuticals, 58(1), 20-22. https://doi.org/10.1002/jlcr.3257

Abstract

Radiolabeled steroid derivative 1 was successfully prepared using a Horner-Wadsworth-Emmons approach: a [C-14]-label was efficiently incorporated into the C-18 position of the molecule. Previously published procedures employing other olefination methods are either not applicable due to unavailability of [C-14]-precursors or suffer from poor reactivity.

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