• Journal Article

Synthesis and resolution of the benzomorphan-based kappa opioid agonist bremazocine

Citation

Thomas, J., Brieaddy, L., Boldt, K., Perretta, C., & Carroll, F. (2007). Synthesis and resolution of the benzomorphan-based kappa opioid agonist bremazocine. Synthesis, 2007(10), 1481-1484. DOI: 10.1055/s-2007-966026

Abstract

An efficient synthesis of racemic bremazocine hydrochloride salt was developed. The racemic material was resolved using (+)- and (-)-3-bromocamphorsulfonic acid ammonium salt to give optically pure samples of (-)- and (+)-bremazocine