Regioselective couplings of dibromopyrrole esters
The regioselectivity of the Suzuki couplings of several 4,5- and 3,4-dibromopyrrole-2-carboxylate esters has been studied. In general, regioselectivity can be achieved for initial coupling at the more electron-deficient site (C5 and C3, respectively). At the same time, conversions are often modest (40-60%) and attempts to force the reactions to higher conversions often lead to competitive dicoupling.
Handy, ST., & Zhang, Y. (2006). Regioselective couplings of dibromopyrrole esters. Synthesis, 2006(22), 3883-3887. DOI: 10.1055/s-2006-950305