A practical, laboratory-scale synthesis of perampanel
McElhinny, C., Carroll, F., & Lewin, A. (2012). A practical, laboratory-scale synthesis of perampanel. Synthesis, 2012(1), 57-62. DOI: 10.1055/s-0031-1289587
The orally active, noncompetitive, selective AMPA receptor antagonist Perampanel, 2-[1',6'-dihydro-6'-oxo-1-phenyl-(2',3'-bipyridin)-5'-yl]benzonitrile, has been prepared from readily available, relatively inexpensive starting materials. The synthesis was carried out on a laboratory scale with no specialized equipment, and involved only two chromatographic purifications.