Four stereoisomeric hybrids of the polyketide natural products callystatin A and leptomycin B have been prepared by parallel synthetic routes involving chiral allenylstannane methodology. Like their natural counterparts, these hybrids exhibit nanomolar levels of cytotoxicity toward HCT-116 human colon cancer cells.
Leptostatin: A synthetic hybrid of the cytotoxic polyketides callystatin A and leptomycin B
Marshall, JA., Mikowski, AM., Bourbeau, MP., Schaaf, GM., & Valeriote, F. (2006). Leptostatin: A synthetic hybrid of the cytotoxic polyketides callystatin A and leptomycin B. Bioorganic and Medicinal Chemistry Letters, 16(2), 320-323. https://doi.org/10.1016/j.bmcl.2005.09.084