Leptostatin: A synthetic hybrid of the cytotoxic polyketides callystatin A and leptomycin B
Four stereoisomeric hybrids of the polyketide natural products callystatin A and leptomycin B have been prepared by parallel synthetic routes involving chiral allenylstannane methodology. Like their natural counterparts, these hybrids exhibit nanomolar levels of cytotoxicity toward HCT-116 human colon cancer cells.
Citation
Marshall, J. A., Mikowski, A. M., Bourbeau, M. P., Schaaf, G. M., & Valeriote, F. (2006). Leptostatin: A synthetic hybrid of the cytotoxic polyketides callystatin A and leptomycin B. Bioorganic and Medicinal Chemistry Letters, 16(2), 320-323. DOI: 10.1016/j.bmcl.2005.09.084
