The invention provides hydroxybupropion analogues capable of inhibiting the reuptake of one or more monoamines and/or acting as antagonists at nicotinic acetylcholine receptors. The compounds may selectively bind to one or more monoamine transporters, including those for dopamine, norepinephrine, and serotonin and/or may selectively bind to one or more nicotinic acetylcholine receptor subtypes. Such compounds may be used to treat conditions that are responsive to modification of monoamine levels and/or antagonism of nicotinic acetylcholine receptors, including drug dependency, depression, and obesity.
Hydroxybupropion analogues for treating drug dependence
Carroll, F., Blough, B., Navarro, H., Mascarella, S., Muresan, AZ., Damaj, MI., & Lukas, RJ. (2014). Hydroxybupropion analogues for treating drug dependence. (U.S. Patent No. 8906908). http://patft.uspto.gov/netacgi/nph-Parser?patentnumber=8906908