The invention provides hydroxybupropion analogs capable of inhibiting the reuptake of one or more monoamines and/or acting as antagonists at nicotinic acetylcholine receptors. The compounds may selectively bind to one or more monoamine transporters, including those for dopamine, norepinephrine, and serotonin and/or may selectively bind to one or more nicotinic acetylcholine receptor subtypes. Such compounds may be used to treat conditions that are responsive to modification of monoamine levels and/or antagonism of nicotinic acetylcholine receptors, including drug dependency, depression, and obesity.
Hydroxybupropion analogues for treating drug dependence
Carroll, F., Blough, B., Navarro, H., Mascarella, S., Muresan, A., Damaj, M. I., & Lukas, RJ. (2016). Hydroxybupropion analogues for treating drug dependence. (U.S. Patent No. 9,527,823). http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=9,527,823.PN.&OS=PN/9,527,823&RS=PN/9,527,823