Hydroxybupropion analogues for treating drug dependence
Carroll, F., Blough, B., Navarro, H., Mascarella, S., Muresan, A., Damaj, M. I., & Lukas, R. J. (2016). Hydroxybupropion analogues for treating drug dependence (Patent No. 9,527,823.)
The invention provides hydroxybupropion analogs capable of inhibiting the reuptake of one or more monoamines and/or acting as antagonists at nicotinic acetylcholine receptors. The compounds may selectively bind to one or more monoamine transporters, including those for dopamine, norepinephrine, and serotonin and/or may selectively bind to one or more nicotinic acetylcholine receptor subtypes. Such compounds may be used to treat conditions that are responsive to modification of monoamine levels and/or antagonism of nicotinic acetylcholine receptors, including drug dependency, depression, and obesity.