Human Immunodeficiency Virus (HIV) Type 1 Infection Status and In Vitro Susceptibility to HIV Infection Among High-risk, HIV-1 Seronegative Hemophiliacs
Blood samples were obtained from 16 hemophiliacs who had a 50%-94% defined risk of human immunodeficiency virus (HIV) type 1 infection on the basis of treatment history and from 14 controls not at risk for HIV infection. HIV-1 was not detected in any of 12 patient samples by cocultivation nor in 14 patient samples by the polymerase chain reaction. Peripheral blood cells from 7 seronegative hemophiliacs at highest risk of seroconversion (94%) were less susceptible to HIV-1 infection in vitro than were cells from healthy controls (P < .025, one-tailed Wilcoxon rank sum test). In contrast, the susceptibility to HIV-1 infection of lymphocytes from 6 seronegative hemophiliacs at moderate risk (50%-56%) of seroconversion did not differ from that of cells from controls or from high-risk hemophiliacs. Therefore, prolonged periods of seronegative HIV-1 infection are not common in this high-risk population. In addition, among hemophiliacs there may exist heterogeneity in susceptibility to HIV-1 infection in vitro and in vivo.
Lederman, M. M., Jackson, J. B., Kroner, B., White III, G. C., Eyster, M. E., Aledort, L. M., ... Goedert, J. J. (1995). Human Immunodeficiency Virus (HIV) Type 1 Infection Status and In Vitro Susceptibility to HIV Infection Among High-risk, HIV-1 Seronegative Hemophiliacs. The Journal of Infectious Diseases, Vol. 172(1), 228 - 231.